Press Releases

Title: *

Category: *

User/Subject: *

Author Name: *

Unit: *

CTL/Team Lead Name: *

AME Name: *

Description: *

A range of immune cells and inflammatory mediators are involved in the <a href="https://www.walshmedicalmedia.com/vascular-medicine-surgery.html">chronic inflammatory illness</a> known as Coronary Heart Disease (CHD). The origin of CHD is unknown, and its pathophysiology is complex and varied. To maximize the advantages of medical intervention, early-stage CHD must be detected. It has been suggested that CD4+T cells, macrophages, neutrophils, high-sensitivity C-reactive protein, IL-6, and GMCSF play a part in the onset and progression of CHD. The condition necessary for CHD is atherosclerosis. Immune cells from the blood, such as mast cells, macrophages, and T lymphoid cells, make up the majority of atherosclerotic plaques. T lymphoid cells among them are significant. In the underlying atherosclerotic lesions, T helper (Th)1 and T helper (Th)17 cells had an active pro-inflammatory state. Interferon-gamma (IFN-), a potent pro-inflammatory cytokine that is mostly produced by Th1 cells, has been found in atherosclerotic plaques in both people and animals. Th17 cells produce IL-17 and, to a lesser extent, TNF- and Interleukin-6, which are both essential for the growth of <a href="https://www.walshmedicalmedia.com/vascular-medicine-surgery/archive.html">atherosclerotic lesions</a>. Although its mechanism is still unknown, it has recently become widely accepted that Th cells (ThGM) that produce GM-CSF play a role in the onset and development of various autoimmune disorders. The IL-7-STAT5 pathway aided in the promotion of GM-CSF expression in ThGM. GM-CSF are pro-inflammatory cytokines that participate in the pathogenesis of many kinds of autoimmune diseases, such as Experimental Autoimmune Encephalomyelitis (EAE), Multiple Sclerosis (MS), and Myasthenia Gravis (MG). In MG patients, the frequency of GM-CSF-producing T cells was decreased in the blood, but enriched in the inflamed thymus. Additionally, the frequency of T cells that produce GM-CSF in the thymus and the severity of MG patients' clinical condition were associated. Although its mechanism is still unknown, it has recently become widely accepted that Th cells (ThGM) that produce GM-CSF play a role in the onset and development of various autoimmune disorders. The IL-7-STAT5 pathway aided in the promotion of GM-CSF expression in ThGM. Multiple Sclerosis (MS), Experimental Autoimmune Encephalomyelitis (EAE), and myasthenia gravis are among the autoimmune illnesses that are influenced by pro-inflammatory cytokines called GM-CSF (MG). In MG patients, the frequency of GM-CSF-producing T cells was decreased in the blood, but enriched in the inflamed thymus. Additionally, the frequency of T cells that produce GM-CSF in the thymus and the severity of MG patients' clinical condition were associated. Patients with CHD have more ThGM cells, but there is no rise in plasmatic GM-CSF.

The <a href="https://www.walshmedicalmedia.com/vascular-medicine-surgery/instructionsforauthors.html">Journal of Vascular Medicine and Surgery</a> is a world-wide peer-reviewed open-access journal which systematically documents several of key developments and medical advances taking place in the field of vascular biology all across the world.

Submit manuscript at <a href="https://www.walshmedicalmedia.com/submissions/vascular-medicine-surgery.html" title="Click here">https://www.walshmedicalmedia.com/submissions/vascular-medicine-surgery.html </a>or send as an e-mail attachment to the Editorial Office at editor.jvms[at]eclinicalres[dot]org

Image: *

Add / Edit Press Release