Blau Syndrome is an autosomal dominant genetic inflammatory disorder that affects the skin, eyes, and joints. It is caused by a mutation of the NOD2 (CARD15) gene. Symptoms typically starting before 4 years of age, with early onset of skin sarcoidosis, granulomatous arthritis, and uveitis. Elucidation that the gene deficiency in BS includes the CARD15/NOD2 gene has prompted many investigators to identify how this gene functions as part of the innate immune system that reacts to bacterial polysaccharides, such as muramyl dipeptide, to induce signaling pathways that cause cytokine reactions and to protect the organism. Treatment has included the usual anti-inflammatory drugs such as adrenal glucocorticoids, anti-metabolites and also biological agents such as anti-TNF and infliximab all with varying degrees of success. Share your comments on topic Email us: clingenom@peerreviewedjournal.org Submit your submission through direct online link: https://www.scitechnol.com/submission/ For more information visit our website: https://www.scitechnol.com/ We accept more than one paper for one author you can also go for membership.